The complex admixture history and recent southern origins of Siberian populations

  20 Март 2016
                 
                        
  1. Irina Pugach1,*,                     
  2.                     
  3. Rostislav Matveev2,                     
  4.                     
  5. Viktor Spitsyn3,                     
  6.                     
  7. Sergey Makarov3,                     
  8.                     
  9. Innokentiy Novgorodov4,                     
  10.                     
  11. Vladimir Osakovsky5,                     
  12.                     
  13. Mark Stoneking1 and                     
  14.                     
  15. Brigitte Pakendorf6,*
  16.                  

- Author Affiliations

                                    

  1. 1Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany                        
                        
  2.                    
  3. 2 Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany                        
                        
  4.                     
  5. 3 Research Centre for Medical Genetics, Federal State Budgetary Institution, Moscow, Russian Federation                        
                        
  6.                     
  7. 4 Institute of Foreign Philology and Regional Studies, North-Eastern Federal University, Yakutsk, Russian Federation                        
                        
  8.                     
  9. 5 Institute of Health, North-Eastern Federal University, Yakutsk, Russian Federation                        
                        
  10.                     
  11. 6 Laboratoire Dynamique du Langage, UMR5596, CNRS and Université Lyon Lumière 2, Lyon, France.                        
                        
  12.             

                 

                        
  1. *Corresponding authors: Этот адрес электронной почты защищен от спам-ботов. У вас должен быть включен JavaScript для просмотра. (IP), Этот адрес электронной почты защищен от спам-ботов. У вас должен быть включен JavaScript для просмотра. (BP)                     
  2.                  

              

                        
  • Received December 9, 2015.                     
  •                     
  • Revision received March 5, 2016.                     
  •                     
  • Accepted March 9, 2016.   
                 

Abstract

                 

Although Siberia was inhabited by modern humans at an early stage, there is still debate over whether it remained habitable                      during the extreme cold of the Last Glacial Maximum or whether it was subsequently repopulated by peoples with recent shared                      ancestry. Previous studies of the genetic history of Siberian populations were hampered by the extensive admixture that appears                      to have taken place among these populations, since commonly used methods assume a tree-like population history and at most                      single admixture events. Here we analyze geogenetic maps and use other approaches to distinguish the effects of shared ancestry                      from prehistoric migrations and contact, and develop a new method based on the covariance of ancestry components, to investigate                      the potentially complex admixture history. We furthermore adapt a previously devised method of admixture dating for use with                      multiple events of gene flow, and apply these methods to whole-genome genotype data from over 500 individuals belonging to                      20 different Siberian ethnolinguistic groups. The results of these analyses indicate that there have been multiple layers                      of admixture detectable in most of the Siberian populations, with considerable differences in the admixture histories of individual                      populations. Furthermore, most of the populations of Siberia included here, even those settled far to the north, appear to                      have a southern origin, with the northward expansions of different populations possibly being driven partly by the advent                      of pastoralism, especially reindeer domestication. These newly developed methods to analyse multiple admixture events should                      aid in the investigation of similarly complex population histories elsewhere.                  

               

                            

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly                      cited.                  

              

      Publised: http://mbe.oxfordjournals.org/cgi/reprint/msw055?ijkey=N8fiJJ4mk9tzM7U&keytype=ref